Sputum and bronchial secretion samples are equally useful as bronchoalveolar lavage samples for the diagnosis of invasive pulmonary aspergillosis in selected patients

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Bronchoalveolar Lavage Fluid Galactomannan for Diagnosis of Invasive Pulmonary Aspergillosis

To the Editor—We read the article by Maertens et al [1] with great interest. In a series of 58 patients who received a diagnosis of proven or probable invasive aspergillosis (IA), the authors confirmed previous work that the diagnostic performance of galactomannan antigen levels in bronchoalveolar lavage (BAL) fluid samples is good and that the procedure is safe in critically ill hematology pat...

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Bronchoalveolar lavage fluid galactomannan for diagnosis of invasive pulmonary aspergillosis.

To the Editor—We read the article by Maertens et al [1] with great interest. In a series of 58 patients who received a diagnosis of proven or probable invasive aspergillosis (IA), the authors confirmed previous work that the diagnostic performance of galactomannan antigen levels in bronchoalveolar lavage (BAL) fluid samples is good and that the procedure is safe in critically ill hematology pat...

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Detection of galactomannan in bronchoalveolar lavage fluid samples of patients at risk for invasive pulmonary aspergillosis: analytical and clinical validity.

Invasive pulmonary aspergillosis (IPA) is frequent and often fatal in immunosuppressed patients. Timely diagnosis of IPA improves survival but is difficult to make. We examined the analytical and clinical validity of galactomannan (GM) testing of bronchoalveolar lavage (BAL) fluid in diagnosing IPA in a mixed population by retrospectively reviewing records of 251 consecutive at-risk patients fo...

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Galactomannan testing of bronchoalveolar lavage fluid is useful for diagnosis of invasive pulmonary aspergillosis in hematology patients

BACKGROUND Invasive pulmonary aspergillosis (IPA) is a major cause of morbidity and mortality in patients with hematological malignancies in the setting of profound neutropenia and/or hematopoietic stem cell transplantation. Early diagnosis and therapy has been shown to improve outcomes, but reaching a definitive diagnosis quickly can be problematic. Recently, galactomannan testing of bronchoal...

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Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients

Background We evaluated the utility of galactomannan (GM) in bronchoalveolar lavage fluid (BALF) for the diagnosis of invasive pulmonary aspergillosis (IPA) in nonneutropenic patients. Methods A total of 183 patients were included in the final analysis. Bronchoscopies and the detection of GM in BALF were all performed on them. Results Ten cases of IPA were diagnosed. ROC data demonstrated t...

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ژورنال

عنوان ژورنال: Medical Mycology

سال: 2015

ISSN: 1460-2709,1369-3786

DOI: 10.1093/mmy/myu090